Dennis W Dickson Selected Research

Lewy Body Disease (Lewy Body Dementia)

1/2022	APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.
1/2022	Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures.
12/2021	Neuropathology and molecular diagnosis of Synucleinopathies.
11/2021	Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids.
1/2021	MRI quantitative susceptibility mapping of the substantia nigra as an early biomarker for Lewy body disease.
1/2021	TAR DNA-Binding Protein 43 Is Associated with Rate of Memory, Functional and Global Cognitive Decline in the Decade Prior to Death.
11/2020	Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein.
11/2020	Confirmation of 123I-FP-CIT SPECT Quantification Methods in Dementia with Lewy Bodies and Other Neurodegenerative Disorders.
5/2020	TDP-43 is associated with a reduced likelihood of rendering a clinical diagnosis of dementia with Lewy bodies in autopsy-confirmed cases of transitional/diffuse Lewy body disease.
1/2020	Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease.

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Dennis W Dickson Research Topics

Disease

111	Alzheimer Disease (Alzheimer's Disease) 02/2022 - 10/2003
77	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 02/2022 - 05/2005
73	Frontotemporal Dementia (Semantic Dementia) 02/2022 - 10/2003
63	Dementia (Dementias) 01/2022 - 01/2002
51	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 11/2002
41	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2002
40	Tauopathies 01/2022 - 06/2002
39	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2022 - 02/2004
37	Parkinsonian Disorders (Parkinsonism) 02/2022 - 01/2002
37	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 08/2008
34	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 10/2002
23	Cognitive Dysfunction 02/2022 - 01/2004
21	Atrophy 01/2022 - 04/2005
21	Synucleinopathies 12/2021 - 10/2004
21	Multiple System Atrophy 01/2021 - 01/2004
20	Corticobasal Degeneration 06/2022 - 10/2003
18	Amyloid Plaque 01/2019 - 10/2002
11	Hippocampal Sclerosis 01/2020 - 01/2004
10	Pick Disease of the Brain (Pick's Disease) 01/2021 - 11/2003
10	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2021 - 05/2005
9	Gliosis 11/2020 - 10/2002
8	Proteostasis Deficiencies 01/2022 - 07/2008
6	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 11/2021 - 05/2015
6	TDP-43 Proteinopathies 11/2020 - 07/2008
5	Disease Progression 01/2022 - 07/2008
5	Neuroinflammatory Diseases 09/2021 - 11/2006
5	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 07/2010
4	Ischemia 01/2008 - 09/2005
3	Hallucinations (Hallucination) 02/2022 - 08/2016
3	REM Sleep Behavior Disorder 02/2022 - 08/2016
3	COVID-19 01/2022 - 02/2021
3	Cerebellar Ataxia (Dysmetria) 01/2022 - 09/2008
3	Chronic Traumatic Encephalopathy 12/2021 - 01/2016
3	Ataxia (Dyssynergia) 12/2020 - 06/2004
3	Amyloidosis 11/2020 - 01/2014
3	Memory Disorders (Memory Loss) 01/2019 - 01/2014
3	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2019 - 10/2008
3	Weight Loss (Weight Reduction) 01/2018 - 08/2017
3	Tremor (Tremors) 01/2016 - 09/2003
3	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2016 - 06/2008
3	Inflammation (Inflammations) 01/2015 - 01/2008
3	Neoplasms (Cancer) 08/2013 - 06/2004
3	Globoid Cell Leukodystrophy (Krabbe Disease) 08/2007 - 09/2005
2	Demyelinating Diseases (Demyelinating Disease) 05/2022 - 01/2020
2	Rupture 02/2021 - 01/2017
2	Disease Susceptibility (Diathesis) 01/2021 - 10/2013
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2021 - 08/2011

Drug/Important Bio-Agent (IBA)

78	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
53	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2022 - 05/2007
51	Amyloid (Amyloid Fibrils)IBA 01/2022 - 10/2003
37	SynucleinsIBA 01/2022 - 01/2007
36	UbiquitinIBA 01/2021 - 04/2003
33	ProgranulinsIBA 01/2021 - 11/2006
29	Apolipoproteins E (ApoE)IBA 11/2021 - 01/2003
23	alpha-SynucleinIBA 12/2020 - 08/2002
21	Biomarkers (Surrogate Marker)IBA 06/2022 - 01/2007
21	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2021 - 04/2003
20	ApolipoproteinsIBA 01/2022 - 01/2002
15	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2003
14	Amyloid beta-PeptidesIBA 01/2021 - 10/2002
13	tau Proteins (tau Protein)IBA 11/2019 - 07/2004
13	Phosphotransferases (Kinase)IBA 01/2017 - 12/2005
12	Levodopa (L Dopa)FDA LinkGeneric 02/2022 - 01/2002
12	Protein Isoforms (Isoforms)IBA 01/2022 - 06/2002
12	RNA (Ribonucleic Acid)IBA 01/2022 - 12/2003
11	Leucine (L-Leucine)FDA Link 01/2017 - 05/2007
8	Apolipoprotein E4IBA 01/2022 - 05/2005
7	DipeptidesIBA 01/2021 - 01/2017
7	Peptides (Polypeptides)IBA 11/2020 - 12/2005
6	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 11/2020 - 01/2016
6	Presenilin-1IBA 01/2017 - 06/2007
5	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2022 - 10/2012
5	Carrier Proteins (Binding Protein)IBA 01/2022 - 08/2012
5	Monoclonal AntibodiesIBA 11/2020 - 06/2002
5	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 11/2002
5	EnzymesIBA 12/2017 - 09/2005
5	Messenger RNA (mRNA)IBA 09/2013 - 01/2010
4	LipidsIBA 05/2022 - 04/2004
4	AntibodiesIBA 01/2020 - 06/2002
4	MicroRNAs (MicroRNA)IBA 01/2016 - 12/2008
3	Mitochondrial DNA (mtDNA)IBA 01/2022 - 01/2020
3	IronIBA 01/2022 - 06/2010
3	Amino Acids FDA Link 01/2022 - 11/2011
3	poly(glycyl-alanyl)IBA 01/2021 - 10/2015
3	NucleotidesIBA 01/2021 - 07/2015
3	PrionsIBA 11/2019 - 01/2016
3	Biological ProductsIBA 12/2018 - 11/2017
3	Protein AggregatesIBA 07/2017 - 10/2016
3	Protein Glutamine gamma Glutamyltransferase 2IBA 10/2016 - 01/2008
3	N 30IBA 01/2015 - 01/2009
3	Protons (Proton)IBA 12/2014 - 08/2012
3	Neprilysin (Neutral Endopeptidase)IBA 01/2013 - 10/2003
3	GalactosylceramidaseIBA 08/2007 - 09/2005
2	Cholinergic Agents (Cholinergics)IBA 01/2022 - 01/2018
2	IGF-I-IGFBP-3 complex FDA Link 01/2022 - 03/2014
2	CytokinesIBA 01/2022 - 11/2011
2	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 11/2021 - 08/2014
2	Apolipoprotein E3IBA 09/2021 - 01/2020
2	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2021 - 06/2014

Therapy/Procedure

11	Therapeutics 01/2022 - 01/2006